Somatic mutation in Alzheimer's disease
We are interested in understanding how somatic mutations arise in Alzheimer's disease (AD), and what they can teach us about genotoxic mechanisms in brain cells and the downstream effects. We recently reported the first study of the genomes of individual neurons in AD, identifying disease-related somatic mutation patterns. We are now actively examining specific mechanisms of somatic mutation generation in neurodegeneration.
Single-cell genomics technology
We are developing technologies to probe the genome and other features of single cells in the brain, to help us learn about how those cells are affected during disease pathogenesis.
We are fortunate to have generous support from these organizations to further the mission of our research: